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Department of Biology Faculty and Research |
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Department
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Study Abroad - Biology at St Andrews University, Scotland W&L Links
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Professor of Biology and Neuroscience Program member
Education Undergraduate Degree: University College of Wales, Aberystwyth, Great Britain Graduate Degree: University of Kentucky, Lexington, KY Postdoc: University of Michigan, Ann Arbor, MI
Joined W&L Faculty in 1995
Courses Taught at W&L Fundamentals of Biology (Biology 111) Reproductive Physiology (Biology 255)
Integrative Sciences: Cardiovascular Disease (Bio/Engn 265)
Current Research Interests Neurobiology
of Puberty - This is an ongoing project to determine the metabolic signals and sensors within the brain
which transduce metabolic information, and the neurotransmitter
pathways which transmit this metabolic information to the brain region
which controls reproduction (the hypothalamus). Dr. K-I Maeda, Dr. H. Tsukamura (University of Nagoya, Japan) and I continue our long-term collaboration on the site of brain metabolic sensors which monitor available brain energy fuels. Specifically we are interested in the mechanism of action of these sensors and transduction of the resultant signal to regulate reproductive function using the adult female rat as our model. This collaboration has been ongoing since April 1999, and has continued through my 6 month sabbatical in their lab (June-Dec, 2000) until now. Our current work has focused on specific populations of energy sensing mechanisms within the brainstem of adult animals. Dr. Fran Ebling (Nottingham University, UK) and I have recently began a collaboration during my sabbatical leave (2006-2007) which studies the neural regulation of metabolism in the Siberian hamster model that gains and looses weight with season. Our first series of studies investigate the role of histaminergic neurons in the regulation of seasonal metabolic changes in the hamster. We also use the mouse model to determine the role of a novel brain receptor (prokineticin receptor 2) in the regulation of metabolism. Recent Publications (* undergraduate co-authors) I'Anson H, Manning JM, Herbosa MC, Pelt C, Wood RI, Bucholtz, DC, and Foster DL: Central inhibition of gonadotropin-releasing hormone secretion in the growth-restricted hypogonadotropic female sheep. Endocrinology 141:520-527, 2000. Messer NA*, and I’Anson H: The nature of the metabolic signal capable of triggering onset of puberty in food-restricted, prepubertal female rats. Physiol. Behav., 68:377-382, 2000. Reyes BA, Estacio MA, I'Anson H, Tsukamura H, and Maeda KI: Glucoprivation increases estrogen receptor alpha immunoreactivity in the brain catecholaminergic neurons in ovariectomized rats. Neurosci Lett., 299(1-2):109-12, 2001.
Harney
JP, Madara J, Madara J D, and I'Anson
H: Effects of acute inhibition of fatty acid oxidation on latency
to seizure and concentrations of b-hydroxybutyrate in plasma of rats maintained on calorie restriction
and/or the ketogenic diet. Epilepsy
Res., 49:239-246, 2002. I’Anson H, Starer CA*, and Bonnema KR*: Glucoprivic regulation of estrous cycles in the rat. Hormones and Behavior, 43:388-393, 2003. I’Anson H, Sundling LA, Roland SM, and Ritter S: Immunotoxic Destruction of Distinct Catecholaminergic Neuron Populations Disrupts the Reproductive Response to Glucoprivation in Female Rats. Endocrinology, 144:4325-4331, 2003. Kinoshita M*, I’Anson H, Tsukamura H, and Maeda K-I: Fourth ventricular alloxan injection suppresses pulsatile luteinizing hormone release in female rats. J. Reprod. Dev., 50(3):279-285, 2004. Estacio MAC, Tsukamura H, Reyes BAS, Uenoyama Y, I’Anson H, and Maeda K-I: Involvement of brainstem noradrenergic inputs to the hypothalamic paraventricular nucleus (PVN) in estrogen receptor α expression in this nucleus during different stress conditions in female rats. Endocrinology, 145(11):4917-4926, 2004. Reyes BAS, Tsukamura H, I’Anson H, Estacio MAC, Hirunagi K, and Maeda K-I Temporal expression of estrogen receptor a in the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons. J. Endocrinology 190:593-600, 2006. Shahab M, Sajapitak S, Tsukamura H, Kinoshita M*, Matsuyama S*, Okhura S, Yamada S*, Uenoyama Y, I’Anson H, and Maeda K-I: Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats. J. Reprod. Devel., 52:763-772, 2006 I’Anson H, Bonnema KR*, Simpson EE*, Dougherty EJ*, Chartisathian K*, Kitchens KG*, Vassallo MA*, Markham JA*, Howenstein MJ*, Meyers EA*, Russell KA*, Magee S*, Khana S*, and Hinkle LL*: Glucose availability as a signal timing puberty in female rats. In preparation, 2007 Jethwa PJ., I’Anson H, Warner A, Prosser HM, Bradley A, Hastings MH, Maywood ES, Ebling FJP: Loss of prokinetcin receptor 2 (ProkR2) signaling predisposes mice to torpor. In preparation, 2007 Hickman CP, Roberts LS, Larson A, and I’Anson, H: “Integrated Principles of Zoology” 12th edition, McGraw Hill (pubs), 2003. Hickman CP, Roberts LS, Larson A, and I’Anson H: “ Integrated Principles of Zoology” 13th edition, McGraw Hill (pubs), 2005. Hickman CP, Roberts LS, Keen S, Larson A, I’Anson H, and Eisenhour DJ: “ Integrated Principles of Zoology” 14th edition, McGraw Hill (pubs), 2007.
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